2017 Fiscal Year Final Research Report
Impact of hydroxylation signals on homeostatic regulation of hematopoiesis
| Project/Area Number |
15H04861
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Takubo Keiyo 国立研究開発法人国立国際医療研究センター, その他部局等, 生体恒常性プロジェクト長 (50502788)
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| Research Collaborator |
KOBAYASHI Hiroshi
MORIKAWA Takayuki
KARIGANE Daiki
TAMAKI Shinpei
HARAGUCHI Miho
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 造血幹細胞 / 低酸素応答 / ニッチ細胞 |
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| Outline of Final Research Achievements |
Hematopoietic stem cells (HSCs) exhibit multilineage differentiation and self-renewal activities that maintain the entire hematopoietic system during an organism's lifetime. These abilities are sustained by intrinsic transcriptional programs and extrinsic cues from the microenvironment or niche. In this study we have clarified a pivotal role of proryl hydroxylase (Phd) family genes in maintenance of stem cell capacity, cell cycle, and transplantation ability of HSCs. We also clarified a crucial role of hypoxia-inducible factor expressed in niche cells in generation of differentiated hematopoietic cells.
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| Free Research Field |
血液学・幹細胞生物学
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