Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04870
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kumamoto University
• Principal Investigator: Matsushita Shuzo 熊本大学, エイズ学研究センター, 教授 (00199788)
• Co-Investigator(Kenkyū-buntansha): 佐藤 賢文 熊本大学, エイズ学研究センター, 教授 (70402807)
• Co-Investigator(Renkei-kenkyūsha): KUWATA Takeo 熊本大学, エイズ学研究センター, 特任講師 (70346063)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 感染症治療学 / 感染症防御学 / ウイルス / 内科

Outline of Final Research Achievements

HIV-1 infected cells persisting under antiretroviral therapy (ART) are targets for therapeutic development for the cure of HIV-1 infection. We investigated the kinetics of proviral DNA (pDNA) using qPCR for 840 specimens of peripheral blood mononuclear cells (PBMC) of 59 cases under long-term treatment from 1996. When untreated, pDNA was 284 copies on average per million PBMCs, but it decreased with ART initiation. On the other hand, in the course of long-term treatment, pDNA plateaued at a certain level that varies from case to case. In cases with chronic complications, it was inferred that there are different patterns in the kinetics of pDNA under ART, such as repeatedly increasing and decreasing greatly.

Free Research Field

血液学