Induction of tumor-suppressing pancreatic stellate cell subpopulation by pancreatic cancer microenvironment reprogramming

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04933
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418)
• Co-Investigator(Kenkyū-buntansha): 井上 重隆 九州大学, 医学研究院, 共同研究員 (00529802) ; 大内田 研宙 九州大学, 大学病院, 講師 (20452708)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膵臓癌 / 膵星細胞 / 癌微小環境

Outline of Final Research Achievements

We identified subpopulation of CD51 highly expressed pancreatic stellate cells as tumor-promoting pancreatic stellate cells and CD146 highly expressed pancreatic stellate cells as tumor-suppressing pancreatic stellate cells. Endo180 expressed on pancreatic stellate cells was found to be associated with local invasion mechanism as a leading cell of tumor-promoting pancreatic stellate cells. Furthermore, we identified autophagy was involved in the activation of pancreatic stellate cells. In the mouse model, suppression of autophagy of pancreatic stellate cells reduced tumor development and metastasis. From these results, we clarified the possibility of a new treatment strategy by reprogramming cancer microenvironment.

Free Research Field

医歯薬学