The role of extracellular vesicles in development of metastasis of gastrointestinal cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04934
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Otsuji Eigo 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600)
• Co-Investigator(Kenkyū-buntansha): 市川 大輔 山梨大学, 大学院総合研究部, 教授 (20347446) ; 塩崎 敦 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40568086) ; 小松 周平 京都府立医科大学, 医学(系)研究科(研究院), 特任講師 (40578978) ; 小西 博貴 京都府立医科大学, 医学部附属病院, 研究員 (00448739) ; 有田 智洋 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00756794)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: exosome / 胃癌 / 腹膜播種 / 腹水 / ファイブロネクチン-1 / ラミニンガンマ-1

Outline of Final Research Achievements

Tumor-derived exosome (TEX) were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner. Expression of adhesion- related molecules, such as fibronectin 1 (FN1) and laminin gamma 1 (LAMC1), were increased in mesothelial cells after internalization of TEX from gastric cancer cell line and malignant pleural effusion. Immunohistochemistry demonstrated higher expression of FN1 and LAMC1 in the disseminated peritoneal membrane than in the benign peritoneal membrane.

Free Research Field

消化器外科学