2017 Fiscal Year Annual Research Report
Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse
| Project/Area Number |
15H04972
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| Research Institution | University of Yamanashi |
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Principal Investigator |
武田 正之 山梨大学, その他部局等, 理事 (80197318)
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| Co-Investigator(Kenkyū-buntansha) |
小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752)
富永 真琴 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90260041)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | nocturia / clock gene / noctrunal polyuria / metabolomics |
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| Outline of Annual Research Achievements |
1.We conclude that The sensation of bladder fullness may have a circadian rhythm, which is created by functional circadian changes of Piezo1 and TRPV4 being controlled by clock genes to be active during wakefulness and inactive during sleep. Abnormalities of clock genes disrupt sensation of bladder fullness, and induce nocturia.
2.We identified metabolites using a metabolomics approach and investigated the association between these metabolites and lower urinary tract symptoms. Male lower urinary tract symptoms may develop due to abnormal metabolic processes in some pathways. Potential new treatments for lower urinary tract symptoms can be developed by identifying changes in the amino acid profiles.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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Research Products
(6 results)
