2017 Fiscal Year Final Research Report
Studies on lower urinary tract dysfunction pathogenesis by complex systems network and dynamic homeostasis collapse
| Project/Area Number |
15H04972
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752)
富永 真琴 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90260041)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIYAMA Mitsuharu 山梨大学, 大学院総合研究部, 医学研究員 (20422694)
SAWADA Norifumi 山梨大学, 大学院総合研究部, 講師 (70402055)
KIRA Satoru 山梨大学, 大学院総合研究部, 助教 (10530115)
IHARA Tatsuya 山梨大学, 大学院総合研究部, 助教 (90622407)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Lower urinary tract / Clock genes / Mechanosensor / Metabolomics / Biomarker |
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| Outline of Final Research Achievements |
We demonstrated that ClockD19/D19 mice showed the phenotype of NOC/NP. The ClockD19/D19 mouse may be used as an animal model of NOC and NP.The gene expression of mechanosensor, Cx26 and VNUT was maintained at a higher level in spite of the sleep phase.We demonstrated that the time-dependent gene expressions, including clock genes, mechano-sensors, and ARMM, were reproducible in UCs. These findings demonstrated that UCs have the potential to progress research into the circadian functions of the lower urinary tract regulated by clock genes.The expressions of Cxs and TRP channels on urothelial cells in voided urine could be related to LUTS. Male lower urinary tract symptoms may develop due to abnormalmetabolic processes in some pathways. Potential new treatments for lower urinary tract symptoms can be developed by identifying changes in the amino acid profiles.
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| Free Research Field |
泌尿器科学
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