Elucidation of refractory mechanism to the molecular targeted therapy for renal cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04977
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: Oya Mototsugu 慶應義塾大学, 医学部(信濃町), 教授 (00213885)
• Co-Investigator(Kenkyū-buntansha): 菊地 栄次 慶應義塾大学, 医学部(信濃町), 准教授 (10286552) ; 三上 修治 慶應義塾大学, 医学部(信濃町), 講師 (20338180) ; 小坂 威雄 慶應義塾大学, 医学部, 助教 (30445407) ; 篠島 利明 慶應義塾大学, 医学部(信濃町), 講師 (60306777) ; 水野 隆一 慶應義塾大学, 医学部(信濃町), 講師 (60383824) ; 浅沼 宏 慶應義塾大学, 医学部(信濃町), 准教授 (70245570) ; 宮嶋 哲 慶應義塾大学, 医学部(信濃町), 准教授 (90245572)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腎細胞癌 / 分子標的治療 / 治療抵抗性 / リスク分類

Outline of Final Research Achievements

Aryl hydrocarbon receptor (AhR) was investigated in 120 patients with RCC using immunohistochemistry. AhR was predominantly expressed in the nuclei of high-grade clear cell RCC (ccRCC) and tumor-infiltrating lymphocytes (TILs), and its expression levels in cancer cells and TILs correlated with the pathological tumor stage and histological grade.
Expression of VASH1 were immunohistochemically examined. Multivariate Cox analysis indicated that an elevated VASH1 density, but not microvascular density, was a significant and independent predictor of overall survival (odds ratio, 7.71; P=0.003). Blood samples were collected at baseline in 90 patients to analyze serum angiogenic and inflammatory markers together with peripheral blood immunological marker. Immunologic (myeloid-derived suppressor cells, percentage of T helper type 1 cells) markers at baseline predicted the response to sunitinib therapy and/or disease progression in patients with metastatic renal cell carcinoma.

Free Research Field

泌尿器科学、腫瘍学