2017 Fiscal Year Final Research Report
Identification of the mechanisms of metabolic stress signal for the treatment of oral cancer
| Project/Area Number |
15H05019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高雄 啓三 富山大学, 研究推進機構 研究推進総合支援センター, 教授 (80420397)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Hironori 宮崎大学, 医学部, 特任助教 (40610283)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 小胞体ストレス |
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| Outline of Final Research Achievements |
Cancers that occur frequently in the oral cavity are in a state of low oxygen / low glucose stress because there is not sufficient angiogenesis, and the cancer cells are in a very high metabolic requirement. Under such stress, autophagy is thought to contribute to cell proliferation. In addition, malnutrition leads to accumulation of bad proteins and ER stress-induced survival / proliferation signals are transmitted. One way to overcome oral cancers in a stress tolerant state is to suppress the survival signal transmitted from autophagy or the endoplasmic reticulum and to induce a cell death signal due to strong endoplasmic reticulum stress. In this study, the metabolic stress signal in cancer cells was elucidated.
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| Free Research Field |
細胞生物学
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