2017 Fiscal Year Final Research Report
Epiprofin regulation in cell proliferation and differentiation in tooth development
| Project/Area Number |
15H05032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福本 敏 東北大学, 歯学研究科, 教授 (30264253)
江草 宏 東北大学, 歯学研究科, 教授 (30379078)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | エナメル芽細胞 / 転写因子 / エピプロフィン / 歯の再生 |
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| Outline of Final Research Achievements |
We previously identified Epiprofin(Epfn) as a novel member of Sp transcription factor family that is expressed in certain ectodermal organs, such as teeth, hair follicles, nails and skin. During tooth development, Epfn regulates cell proliferation as well as cell migration at the early stages and cell differentiation in the later mature stage by controlling the phosphorylation of Epfn. We also identified a small molecule that strongly induced the expression of Epfn in dental epithelial cells. We are applying the Epfn -inducible small molecule in enamel biosynthesis of regenerative dentistry.
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| Free Research Field |
再生歯学
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