2017 Fiscal Year Final Research Report
A basic study for the development of stem cell-cytokine therapy aimed at the enhancing periodontal tissue regeneration effect.
| Project/Area Number |
15H05034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村上 伸也 大阪大学, 歯学研究科, 教授 (70239490)
柳田 学 大阪大学, 歯学研究科, 招へい教員 (80379081)
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| Research Collaborator |
YAMADA Satoru
TAKEDACHI Masahide
SAWADA Keigo
ANZAI Jun
NAGAYASU Toshie
SAKASHITA Hiromi
YAMAMOTO Tomomi
TSUSHIMA Kenichiro
MORIMOTO Chiaki
HASEGAWA Shiori
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 歯周病 / 再生 / サイトカイン / 幹細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated the possibility of enhancing periodontal regeneration effect in the cell therapy using mesenchymal stem cells and the cytokine therapy. As a result, it was revealed that fibrin gel and β-3 calcium phosphate (β-TCP) whose granule size was 500-1000 mm were useful as a scaffold for adipose tissue-derived stem cells (ADSC). The proteomic analysis of culture supernatants of ADSC and bone marrow- derived mesenchymal stem cells suggested that Periostin might be involved in periodontal tissue regeneration. In addition, the bone regeneration was observed by application of FGF-2 in the fenestration model of beagle dogs. These results suggested that the combination of cell therapy using stem cells and cytokine therapy might enhance the periodontal tissue regeneration effect.
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| Free Research Field |
歯周病学
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