Comprehensive analysis for the genetic background to obesity, diabetes, a periodontal disease and the interaction of environmental, and the metabolic factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05056
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Niigata University
• Principal Investigator: Akihito Yoshihara 新潟大学, 医歯学系, 教授 (50201033)
• Co-Investigator(Kenkyū-buntansha): 宮崎 秀夫 新潟大学, 医歯学系, 教授 (00157629) ; 中村 和利 新潟大学, 医歯学系, 教授 (70207869)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周病 / 遺伝子多型 / 肥満 / 炎症

Outline of Final Research Achievements

We hypothesized that gene polymorphisms such as beta-3 adrenergic receptor, PRR gamma and VDR TaqI might have gene-environmental and gene-gene interactions in periodontal disease. These studies were conducted by 1055 participants aged 55-79 years old. These results showed that chronic kidney disease (CKD) and periodontal disease can have reciprocal effect. In addition, beta-3 adrenergic receptor and PPAR gamma gene polymorphism were not independent risk factor for periodontal disease. However, the interaction between beta-3 adrenergic receptor and PPAR gamma gene poly morphism was associated significantly with periodontal disease in obese elderly females. There might be a correlation between the VDR TaqI genotype and CKD when severe levels of periodontal disease are present, Our studies suggest that there might be a gene-gene or gene-environmental interaction among periodontal disease and each gene polymorphism.

Free Research Field

予防歯科