2018 Fiscal Year Final Research Report
Analysis of Chinese Toxoplasma phylogeny and virulence
| Project/Area Number |
15H05275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
Sasai Miwa
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | トキソプラズマ / 中国 / 病原性 |
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| Outline of Final Research Achievements |
Toxoplasma gondii is an pathogen causing lethal toxoplasmosis in immunocompromised individuals those suffering from AIDS and being treated by chemotherapy. In addition, this pathogen causes congentical diseases when pregnant women are firstly infected. It is postulated that nearly one-third of world populatin are oppupotunistically infected with T. gondii. Therefore, number of T. gondii-infected Japanese people might be also high. However, how Asian T. gondii including Japanese ones acts remains unclear. Therefore, we have analyzed virulence and whole genome information about Chinese T. gondii in collaboration with Chinese parasitologists.
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| Free Research Field |
寄生虫学
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| Academic Significance and Societal Importance of the Research Achievements |
トキソプラズマは免疫不全のヒトで致死的な病気を引き起こす病原体である。世界人口の３分の１が感染していると言われているが、アジアにおける実態はよくわかっていない。そこで中国の寄生虫学者とともに、中国においてトキソプラズマを分離し、その病原性や病原性因子群の遺伝子多型について検討を行った。その結果、複数の中国分離株が得られ、系統によって病原性が異なることが分かり、さらに病原性が強い方では原虫の増殖やマウス個体レベルでのサイトカインストームが起きることが分かった。
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