2017 Fiscal Year Final Research Report
Bacteria on nanotopographic metals
| Project/Area Number |
15H05547
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural/Functional materials
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ナノポーラス / 金 / 抗菌 |
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| Outline of Final Research Achievements |
The origin of high antibacterial properties of nanoporous gold is examined by comparison with flat gold. The tests of antibacterial properties against Escherichia coli (E. coli) and Staphylococcus epidermidis under various relative humidity suggest that the direct contact between nanoporous gold substrate and bacteria is necessary for killing bacteria. This is different from conventional antibacterial metals and alloys which emits diffusive species such as reactive oxygen species and metallic ions. The measurement of elastic modulus of E. coli cultured on gold substrates revealed that the E. coli on nanoporous gold was more stiffened than that on flat gold, which is contrary to the expectation. Atomic simulation and gene expression analyses suggested that the antibacterial mechanism of nanoporous gold is not merely due to the mechanical fracture of cell membrane but originated from complex and subtle conformational change in component such as peptidoglycan and ion channels.
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| Free Research Field |
工学
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