Elucidation of the mechanisms of the slow processes of development, growth and senescence in the longest-lived rodent, the naked mole rat.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05649
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Miura Kyoko 北海道大学, 遺伝子病制御研究所, 招へい教員 (80583062)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ハダカデバネズミ / naked mole rat

Outline of Final Research Achievements

The naked mole rat (NMR) is the longest-living rodent in the world and has extraordinary cancer-resistance. We studied the mechanisms of slow processes of development, growth and senescence in the NMR. We found that temperature and other factors may contribute to slow proliferation of the NMR somatic cells. NMR-iPS cells did not show shortening of G1 phase and acceleration of proliferation compared to the parental skin fibroblasts. We also found a mechanism of NMR-specific metabolic regulation which would contribute to slow proliferation of the NMR somatic cells. Moreover, we also performed functional analysis of the NMR brown adipose tissues.

Free Research Field

老化学、幹細胞学、ハダカデバネズミ学