2017 Fiscal Year Final Research Report
Elucidation of the pathogenesis of rheumatoid arthritis and evaluation of drug mechanism and efficacy by intravital imaging techniques
| Project/Area Number |
15H05671
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 生体イメージング / 二光子励起顕微鏡 / 破骨細胞 / 炎症性骨破壊 / 生物学的製剤 |
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| Outline of Final Research Achievements |
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial joint inflammation and progressive bone destruction. Arthritic bone destruction is considered to be mediated mainly by enhanced activation of osteoclasts at inflammatory sites. To prevent RA-associated bone destruction, it is important to understand the cellular dynamics in inflammatory bone destruction in vivo. In this study, we established an intravital imaging system for visualizing the in vivo behavior of bone-resorbing osteoclasts and their precursors during inflammatory bone destruction. By means of this system, we revealed that various biologics acted at specific therapeutic points during osteoclastic bone destruction, with different efficacies. These results enable us to grasp the real modes of action of drugs, optimizing the usage of drug regimens.
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| Free Research Field |
免疫学
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