2018 Fiscal Year Final Research Report
Construction of clinical application by clarifying the biological basis of proton therapy of cutting edge scanning irradiation method
| Project/Area Number |
15H05675
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Nagoya City University |
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Principal Investigator |
Iwata Hiromitsu 名古屋市立大学, 大学院医学研究科, 研究員 (40611588)
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| Research Collaborator |
SHIBAMOTO yuta
NAKAJIMA koichiro
HASHIMOTO shingo
SUGIE chikao
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 陽子線治療 / 放射線治療 / 放射線生物学 / スキャニング照射 |
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| Outline of Final Research Achievements |
Proton therapy using scanning method combined with high-concentration cisplatin is considered to be very effective. It is suggested that the pattern of cell death and cell cycle may be different, which partly accounts for the difference in the combined effect. Considering the timing of the increase in G2 arrest, potent biological effects may be obtained by delivering proton irradiation during radiosensitive cell cycle phases in chemo-proton therapy. Proton beam irradiation combined with cisplatin resulted in different phenotype as compared with X rays and cisplatin.
The level of mRNA expressions after irradiation were different between proton and X-ray, especially in genes related to DNA repair. Differences of in vivo biological responses between proton and X-ray beams were found.
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| Free Research Field |
放射線治療、陽子線治療
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| Academic Significance and Societal Importance of the Research Achievements |
陽子線治療は、国内外でも広がり、臨床治療がさらに進む方向であるが、いまだに基礎生物学は未解明の問題が多く取り残されている。本研究で、X線と陽子線という線質の違いにより、細胞・個体に対して、様々な表現型の違いが認められ、照射単独では、細胞死という終着点である事象に違いがみられないものもあるが、併用療法によっては、差がみられるものもみられ、より至適な使用方法の開発が急務であることがわかった。このスキャニング照射法での基礎検討は世界でも類をみない検討であり、最先端のがん治療といわれる陽子線治療の礎となるものであり、今後将来の臨床応用の基礎的概念の確立に寄与する、非常に重要なものとなると考えられる。
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