Identification of regeneration associated gene of central nervous system: axon regeneration of corticospinal tract

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H05989
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hokkaido University
• Principal Investigator: KADOYA KEN 北海道大学, 医学研究科, 特任研究助教 (30374276)
• Research Collaborator: Gibbs Daniel University of California, Dept. of Neurosciences ; Tuszynski Mark University of California, Dept. of Neurosciences ; Stobl Hans University of California, Dept. of Neurosciences ; ENDO Takeshi 北海道大学, 医学研究科, 大学院生
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 軸索 / 脊髄損傷 / 再生

Outline of Final Research Achievements

Regeneration associated genes are identified in peripheral but not central nervous system. The purpose of the current study is to determine whether transcription factor cJun is the regeneration associated gene of central nervous system. cJun expressions were manipulated in the experimental model, in which corticospinal tract axons regenerated into grafted cells. Regulation of cJun did not affect the extent of regeneration of corticospinal axons at all, indicating that cJun is not the regeneration associated gene of corticospinal axons and that the central nervous system does not share the mechanism of regeneration with peripheral nervous system.

Free Research Field

整形外科