2016 Fiscal Year Final Research Report
Asymmetric C-H bond functionalization using cobalt catalyst via ligand-directing group interaction
| Project/Area Number |
15H05993
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 不斉触媒 / C-H活性化 / C-H官能基化 / キラルカルボン酸 / キラル対アニオン |
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| Outline of Final Research Achievements |
This project had intended to develop new catalysts for stereoselective and more efficient C-H bond functionalization reactions using interaction between the ligand and directing group. However, it was revealed that new chiral carboxylic acids and introduction of a chiral counter anion can effectively control the stereoselectivity of several reactions during the research. In addition, the scope of high-valent cobalt catalyzed reactions was successfully expanded, and C-H allylation of more general substrates using allyl alcohols, site-selective alkenylation, and trifluoromethylthiolation were achieved.
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| Free Research Field |
有機合成化学
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