2016 Fiscal Year Final Research Report
Proposal of a novel therapy for denture ulcer applying combination of polyphenol and disinfection technique with hydrogen peroxide photolysis
| Project/Area Number |
15H06044
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | ポリフェノール / 酸化ストレス |
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| Outline of Final Research Achievements |
Caffeic acid (CA) and chlorogenic acid (ChA), both of which accelerated proliferation of fibroblasts by short-term treatment, exerted cytoprotected effect on human gingival fibroblast (hGFs) exposed to various harsh and oxidative stressors. In addition, 1-min pretreatment with CA and ChA reduced an inflammatory cytokine TNF-αproduction by human monocyte cell line THP-1 stimulated with LPS derived from Porphyromonas gingivalis, a major causative bacterial species of periodontitis. The results suggest that these polyphenols could be adjunctive agents for disinfection by H2O2 photolysis via cytoprotective and anti-inflammatory effect on ulcer lesion.
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| Free Research Field |
歯科補綴学
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