The establishment of the monitoring the metabolic activity of real human dental plaque in real-time

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H06051
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Ishiguro Kazuko 東北大学, 歯学研究科, 大学院非常勤講師 (00755829)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: プラークバイオフィルム / 代謝 / メタボロミクス / 蛍光色素

Outline of Final Research Achievements

The measurement of the metabolic activity using real human dental plaque has been limited by the technical difficulties. In this study, I established the new method for the measurement. As a result, it was suggested that the metabolism activity was various among individuals, the sample collection part. These results suggested that these variations should be considered for the evaluation of the pathogenicity related to the metabolic activity. In addition, this technique can measure the metabolic activity derived from various substrates including sugars, amino acids. Also, I established the metabolomics technique using human dental plaque. These new methods established in this study give a new viewpoint to the metabolism study of human dental plaque in future.

Free Research Field

口腔生化学、予防歯科学