2016 Fiscal Year Final Research Report
The role of Hippo-YAP pathway in alcohol-induced cardiac dysfunction
| Project/Area Number |
15H06182
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Noritake Kanako 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 (40758067)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | エタノール / 心筋細胞傷害 / Hippo-YAP経路 / 細胞間接着 |
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| Outline of Final Research Achievements |
Excessive alcohol consumption often causes compromised myocardial contractile function, although the precise mechanism remains unknown. We reported previously that when mouse atrium-derived HL-1 cardiomyocytes undergo apoptosis upon direct exposure to ethanol, the cellular cytoskeleton is severely disrupted and the anti-apoptotic transcriptional co-activator YAP is inactivated. The restoration of YAP activation rescues the cells from apoptosis: both the expression of constitutively active YAP and the stabilization of the actomyosin cytoskeleton prevent ethanol-induced cell death. Thus, a decrease in actin tension and YAP inactivation should be crucially involved in the cytotoxicity of ethanol on HL-1 cardiomyocytes.
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| Free Research Field |
法医学
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