Development of a novel method for analyzing repeat sequences

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06185
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ozaki Kokoro 東京医科歯科大学, 医学部附属病院, 助教 (10754765)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 神経内科学 / ゲノム医科学

Outline of Final Research Achievements

In order to find clinically important repeat sequences in human genome, I exploited a bioinformatics approach, which resulted in significantly important repeat sequences. I further developed a novel method to accurately measure the length of the
repeat sequences. For that purpose, I had to develop standard repeat libraries, which will be of use in the future studies. In addition, I tried measuring repeat lengths in a human neurodegenerative disorder. The analysis did not give a significant result. In summary, I found a repeat sequence as a possible risk factor for a human neurodegenerative disorder.

Free Research Field

ゲノム医科学