Molecular mechanism of uptake of Methionine for malignant glioma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06187
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Sumita Kazutaka 東京医科歯科大学, 医学部附属病院, 助教 (70752830)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 悪性神経膠腫 / PET / メチオニン

Outline of Final Research Achievements

When I performed the surgery for malignant glioma in 2015 and 2016, I removed the
part of tumors that MET-PET accumulated using navigation system. I took the 15 pieces of tumor of five patients in this study period. mRNA expression of these samples was analyzed by RNA sequence. I found the candidate of the targets of the treatment. One of them is the enzyme of metabolic pathway of Guanosine triphosphate. The inhibitor of this enzyme cause cell cycle arrest, and I am focusing on the mechanism of cell cycle arrest. I will examine the clinical application of this drug in future.

Free Research Field

脳腫瘍