Periodontal tissue regeneration using controlled release of fibroblast growth factor-2 by electrostatic binding with scaffold

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06190
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: hoshi shu 東京医科歯科大学, 歯学部附属病院, 非常勤講師 (70757210)
• Research Collaborator: AKIZUKI Tatsuya ; MATSURA Takanori ; IZUMI Yuichi
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 線維芽細胞増殖因子-2 / 徐放化 / 歯周組織再生 / 歯周病

Outline of Final Research Achievements

Experiments were carried out on periodontal defect model using beagle dogs. Controlled release of fibroblast growth factor-2 by electrostatic binding with β-TCP acidic gelatin sponge was effective in root cover to gingival recession. Combined use of acidic β-TCP gelatin sponge and fibroblast growth factor-2 was effective for regenerating alveolar bone compared to the combination of basic β-TCP gelatin sponge and fibroblast growth factor-2.In periodontal tissue regeneration therapy, the combination of β-TCP gelatin sponge and fibroblast growth factor-2 was not effective compared with the combination of β-TCP particles and fibroblast growth factor-2.

Free Research Field

歯周病学