Cellular mechanisms underlying anisotropic bone matrix construction

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06361
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Structural/Functional materials
• Research Institution: Osaka University
• Principal Investigator: Matsugaki Aira 大阪大学, 工学研究科, 助教 (10592529)
• Co-Investigator(Renkei-kenkyūsha): NAKANO Takayoshi 大阪大学, 大学院工学研究科, 教授 (30243182)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 骨配向性 / 生体アパタイト結晶 / 細胞配列 / 細胞間相互作用 / オステオサイト

Outline of Final Research Achievements

Bone tissue anisotropy is determined by the osteoblast arrangement. In bone tissue, osteoblast behaviors are regulated by the mutual activities of other types of bone cells. Understanding the cell-cell communication is essential to reveal the molecular mechanisms underlying the anisotropic bone tissue formation. A novel coculture model was established to understand the intercellular communication between osteoblast, osteoclast, and osteocyte. We discovered the mechanosensing by osteocytes regulate the osteoblast arrangement. In addition, the crosstalk between osteoclasts and osteoblasts play key roles in anisotropic bone tissue construction.

Free Research Field

生体材料学