The role of tumor-associated neutrophils in endometrial cancer displaying tumor-related leukocytosis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06378
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: Matsumoto Yuri 大阪大学, 医学部附属病院, 助教 (90756488)
• Research Collaborator: Kuroda Hiromasa ; Kozasa Katsumi ; Yokoi Eriko ; Komura Naoko
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 子宮体癌 / TRL / TAN / 浸潤・転移 / 前転移ニッチ

Outline of Final Research Achievements

Objective: The aim of this study is to investigate the causative mechanism of poor prognosis in endometrial cancer patients displaying TRL (tumor-related leukocytosis), focusing on TAN (tumor-associated neutrophils).
Results and Conclusion: The TAN density of the patient`s endometrial cancer was significantly associated with pretreatment peripheral neutrophils and shorter progression-free-survival. Iv vitro and in vivo experiments revealed that TAN enhanced the invasive capacity and chemotactic activity of endometrial cancer. TAN was infiltrated in the premetastatic lungs and made premetastatic niche, expressing chemoattractant S100a8/9 that attracted the endometrial cancer cells of TRL model. These results indicate that TAN contribute to tumor cell metastases by premetastatic niche formation.

Free Research Field

婦人科腫瘍学