Evaluation of teeth aging by ultrastructural analysis and mechanical properties measurement

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06381
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: KUBO MIZUHO 大阪大学, 歯学部附属病院, 医員 (60757813)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 象牙質 / コラーゲン線維 / 糖化

Outline of Final Research Achievements

Relation between AGEs and systemic disease is known, however, there are few reports about relation between AGEs and teeth. In this study, we analyzed influence of AGEs on teeth. Location of AGEs in dentin collagen was evaluated from results of immunostaining and Young's modulus of dentin collagen was measured with an indenter. As a result, it is clear that AGEs increase in dentin collagen, harden dentin collagen with age, and influence mechanical property of teeth.

Free Research Field

歯科保存学