Dynamic regulation of the genes involved in the neural tube pattern formation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06411
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Sasai Noriaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 (80391960)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 神経管 / パターン形成 / ソニック・ヘッジホッグ / 細胞外シグナル因子

Outline of Final Research Achievements

One of the central questions in the development of the central nervous system is to understand the molecular mechanisms leading to the complex and precise pattern formation of the neural tube. We have been focusing on one of the extracellular signal molecules Sonic Hedgehog (shh), and have attempted to isolate the intracellular factors that regulate the dynamic signal activity in the neural progenitor cells. Consequently we revealed that the negative feedback of the Shh signal activity is essential for the precise pattern formation, and this negative feedback is regulated by a novel G-protein coupled receptor.

Free Research Field

発生生物学