The mechanism of circadian expression of neuromedin U in the pars tuberalis.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06419
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: AIZAWA SAYAKA 岡山大学, 自然科学研究科, 特別契約職員(助教) (90754375)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 下垂体隆起部 / 概日時計 / 生物リズム

Outline of Final Research Achievements

The regulatory mechanism of the expression of neuromedin U (NMU) in the rat pars tuberalis. Quantitative PCR showed that melatonin receptor MT1a and adenosine receptor A2b are highly expressed in the rat pars tuberalis. In rat brain slice culture experiment, NMU mRNA expression was significantly suppressed by melatonin and significantly increased by adenosine. It is suggested that diurnal rhythm expression of NMU in the rat pars tuberalis is antagonistically regulated by adenosine and melatonin.

Free Research Field

内分泌学