Functional analysis of BMP signaling on tooth and limb development

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06423
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Okayama University
• Principal Investigator: Hayano Satoru 岡山大学, 医歯薬学総合研究科, 助教 (20633712)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 細胞死 / 発生 / 歯 / 四肢

Outline of Final Research Achievements

In this study, we investigated the BMP signaling function on tooth and limb formation during their development. We found that BMP ligands and phospho-SMADs were expressed in the area where programed cell death occurs. Further, tooth and limb bud organ culture with p53 inhibitor revealed that p53 pathway plays important role in tooth and limb formation.

Free Research Field

矯正歯科