Volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06448
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: KASAI Asuka 徳島大学, 病院, 特任助教 (90756892)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 吸入麻酔薬 / イソフルラン / オートファジー / 心筋保護 / 虚血再灌流障害 / GLP-1

Outline of Final Research Achievements

We confirmed that volatile anesthetic-induced and GLP-1-induced cardiac preconditioning protects against ischemia-reperfusion injury in mice. Additionally, our results show that volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.

Free Research Field

麻酔科学