Asymmetric Construction of Chiral Knotted Complex Bearing Transition-Metals

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06469
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Kyushu University
• Principal Investigator: Makida Yusuke 九州大学, 理学研究院, 助教 (00752453)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: トポロジー / トポロジカルキラリティ / ノット / 遷移金属錯体触媒 / 不斉合成

Outline of Final Research Achievements

The absolute goal of this study is introducing topological chirality into ligands, which were planning to apply for the asymmetric toransition-metal catalysis. To this aim, I have designed super-long ligand precursor having phosphine coordination sites at both chain termini. Currently, synthesis of the ligand not yet completed. Three bing partial structures have synthesized, and to be coupled them. Meanwhile, bipyridine ligand having two alkene functionalities have synthesized and conducted for complexation with zinc. Then, zinc complex bearing three bipyridine ligands was obtained. Now, we are trying asymmetric olefin metathesis reactions for knotting with occurring kinetic resolution concomitantly.

Free Research Field

有機合成化学