The mechanism of sweet taste perception in taste cells and enteroendocrine cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06485
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: Takai Shingo 九州大学, 歯学研究院, 助教 (30760475)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 味覚 / ホルモン

Outline of Final Research Achievements

In this study, I found the mRNA expression of glucose-dependent insulinotropic polypeptide receptor (GIPR), which was originally identified in gut or pancreas, in mouse taste tissue. Around 70% of GIPR positive taste cells were shown to be expressed with T1R3, sweet-taste receptor subset in mouse taste buds. Additionally, I visited Monell Chemicelsenses Center in the U.S. and learned about newly invented 3-D taste stem cell culture ‘taste organoid’ and create that system also in Japan. In this system, taste stem cells are cultured in the medium with Matrigel and they differentiated to taste cells. The mRNA expression levels of several taste cell markers were increased in an insulin concentration dependent manner in medium. Thus insulin signal may influence the cell growth or proliferation in peripheral taste organs.

Free Research Field

生理学