2016 Fiscal Year Final Research Report
Role of lipid mediator on periodontal tissue regeneration through Wnt5a expression.
| Project/Area Number |
15H06493
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 間葉系幹細胞分化 / スフィンゴシン-1-リン酸 / Wntシグナル伝達経路 |
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is known as the signaling sphingolipid and the bioactive lipid mediator that also plays crucial roles in osteogenic differentiation. In the present study, we investigated the involvement of Wnt signaling on S1P-induced osteogenic differentiation of MSC. We particularly paid attention to β-catenin-dependent and -independent Wnt signaling pathways because both signaling pathways regulate bone formation.
We found that S1P up-regulated Wnt5a expression, leading to the induction of LRP5/6 expression, resulting in the increase of β-catenin-dependent Wnt signaling, and thereby promoting MSC differentiation into osteoblast.
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| Free Research Field |
歯周病学
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