Search for diagnosis and therapy of oral cancer targeting TRP channles

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06497
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Saga University
• Principal Investigator: Reona Aijima 佐賀大学, 医学部, 助教 (30756143)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 口腔癌 / 温度感受性 / TRPチャネル

Outline of Final Research Achievements

Intracellular calcium plays an important role in cancer progression and metastasis. In this study, we investigated the role of transient receptor potential (TRP) channels, Ca2+-permeable nonselective cation channels, in oral squamous cell carcinoma (OSCC).HSC4, well-differentiated OSCC cell line, highly expressed functional TRPV4 channel. Knockdown of TRPV4 showed the change of localization of the adherens junction molecules. Furthermore, TRPV4 silencing induced enhancement of migration in HSC4. Additionally, TRPV4 activation led cell death presumably via JNK/p38 pathway.
These results suggest that TRPV4 wound be a novel therapeutic target for oral cancer therapy.

Free Research Field

外科系歯学