Analysis of the involvement of VTA-M1 pathway on constraint induced movement therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06538
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya City University
• Principal Investigator: UEDA Yoshitomo 名古屋市立大学, 大学院医学研究科, 助教 (30758420)
• Research Collaborator: ISHIDA Akimasa 名古屋市立大学, 大学院医学研究科, 助教 (20632607) ; HIDA Hideki 名古屋市立大学, 大学院医学研究科, 教授 (00305525)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 脳内(内包)出血モデル / 麻痺側集中使用リハビリテーション法(CIMT法) / モチベーション / 中脳皮質ドパミン系 / 二重ウイルス感染法

Outline of Final Research Achievements

Rehabilitation by constraint induced movement therapy (CIMT) improves performance of injured upper limb. To reveal the involvement of midbrain-cortex dopamine pathway, which relates to motivation, in CIMT, we attempted to selectively block ventral tegmental area (VTA) - motor cortex (M1) pathway using two kinds of virus vectors. Obvious result of virus vector infection was not obtained until now. The problem could caused by handling errors of virus vectors and/or manipulation errors of virus injection to the brain. Moreover, we should reconsider the structure of virus vectors and injection sites and number of times. Experimental setup was already prepared, so we continue these trials.

Free Research Field

神経科学