Development and application of novel non-invasive measurement for cerebral blood flow and metabolism using ultra-high field magnetic resonance imaging

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06560
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: Chida Kohei 岩手医科大学, 医学部, 助教 (30611016)
• Research Collaborator: FUJIWARA Shunro 岩手医科大学, 脳神経外科学講座, 助教
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 超高磁場MRI / 脳循環代謝 / 脳酸素摂取率 / IVIM / 拡散強調画像 / 頚動脈内膜剥離術後過灌流

Outline of Final Research Achievements

First, optimal parameters for intravoxel incoherent motion (IVIM）analysis at 7TMRI were defined. And then, the techniques for the fast estimation of the parameters in IVIM analysis such as fivim, D*, ADC was developed and for calculating dCBF map from the IVIM parameters. 7TMRI were performed in 10 healthy subjects and 30 patients with chronic MCA or ICA occlusive disease. Those patients also underwent 15O-PET. The IVIM data are under investigation for comparison with 15O-PET data after the co-registration procedure. While scanning with at least six axis of motion probing gradient was necessary for diffusion tensor (DT) analysis, three axis of motion probing gradient was used to reduce scanning time in this study. As the results, we could not obtain the dCMRO2 map in this time.

Free Research Field

脳血管外科、脳循環代謝、脳核医学