2016 Fiscal Year Final Research Report
Verifying the exacerbating effect of titanium oxide nanoparticles on inflammation
| Project/Area Number |
15H06567
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Meikai University |
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Principal Investigator |
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| Research Collaborator |
SAKAGAMI Hiroshi 明海大学, 歯学部, 教授
OKUDAIRA Noriyuki 明海大学, 歯学部, 助教
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 酸化チタン / 炎症反応 / ナノマテリアル |
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| Outline of Final Research Achievements |
Titanium dioxide (TiO2) nanotube is emerging as a provocative target for oral implant research. The aim of this study was to evaluate the effect of UV on the wettability behavior, bacterial colonization and fibroblast proliferation rate on TiO2 nanotube surfaces prepared using different anodization voltages, aimed to be used an implant abutment material.
UV treatment enhances the wettability behavior of TiO2 nanotube surfaces and could result in lower bacterial adhesion and biofilm formation. Moreover, TiO2 induced inflammatory response in increasing Cyclooxyrgenase (COX-2) expression by western blotting methods.
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| Free Research Field |
口腔外科学
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