Analyzing the mechanisms of perinatal angiogenesis and regulation of tissue oxygen levels

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06591
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Keio University
• Principal Investigator: Asada Nariaki 慶應義塾大学, 医学部(信濃町), 助教 (20757439)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 早産児 / 腎臓 / 低酸素 / エリスロポエチン

Outline of Final Research Achievements

Preterm birth is increasing in the world. Preterm babies develop erythropoietin (EPO)-deficiency anemia of prematurity (AOP). The cause of AOP has been unknown. Furthermore, the course of anemia during development also remained unclear.
We found that the cause of AOP is elevated oxygen levels in the kidney due to poor oxygen consumption by immature tubules. Our findings will help develop therapeutic options for AOP.
In addition, we reported EPO-induced polycythemia in adolescents born preterm with low birth weight. We considered that peritubular capillary rarefaction and progression of focal glomerulosclerosis were causes for the polycythemia.

Free Research Field

新生児学、腎臓学