2016 Fiscal Year Final Research Report
Development of antibody modeling methods toward rational antibody design
| Project/Area Number |
15H06606
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
|
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | 抗体設計 / 蛋白質工学 / データベース / 分子シミュレーション / バイオインフォマティクス |
|---|
| Outline of Final Research Achievements |
The vertebrate adaptive immune systems are capable of promoting cells to degranulate nearly any foreign pathogens by producing antibodies that recognize specific epitopes of antigens. Using existing crystal structures of protein complexes, we revealed peculiar features of various protein complex types, and we quantified shape complementarily of antibody-antigen interfaces. Exploiting docking simulations, we also revealed a stubborn gap in backbone motion not captured by any current computational approaches. Aiming for rational antibody design from amino acid sequences, we also developed antibody modeling methods. An antibody design based on those knowledges are underway.
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| Free Research Field |
生物物理学
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