Development of Ceria-Stabilized Zirconia/Alumina implant

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06609
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University
• Principal Investigator: Oshima Yoko 昭和大学, 歯学部, 助教 (50756442)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 歯科インプラント / 歯科材料 / オッセオインテグレーション

Outline of Final Research Achievements

Ceria-stabilized zirconia/alumina nanocomposite (Ce-TZP/Al2O3) has been widely used for crowns and bridges. Since Ce-TZP/Al2O3 has low susceptibility to hydrothermal degradation, this material has potential to be applied to dental implant fixtures. The aim of this study was to development of Ce-TZP/Al2O3 implant, to investigate the osseointegration capability of the Ce-TZP/Al2O3 implant that was treated with hydrofluoric acid (HF) compared to that of acid-etched titanium implant.
Culture studies using MC3T3-E1 osteoblasts showed that the attachment, spread, and functional phenotypes of osteogenic cells, such as alkaline phosphatase activity, were remarkably increased on nanofeatured Ce-TZP/Al2O3 treated with HF. The strength of osseointegration measured by a biomechanical push-in test in a rat model was stronger for nanofeatured Ce-TZP/Al2O3 implants than for acid-etched titanium at week 2 and 4.

Free Research Field

歯科補綴学