Fundamental study for the development of novel drug delivery system using mono-dispersed emulsion

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06650
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Nippon Medical School
• Principal Investigator: Daisuke Yasui 日本医科大学, 医学部, 助教 (00755001)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 抗癌剤 / エマルジョン / 膜乳化

Outline of Final Research Achievements

Novel drug delivery system was developed to administer highly concentrated anticancer agents to pancreatic cancer, while minimizing normal tissue damage. Ultra-small sized emulsion was developed, which will pass through the normal tissue but will remain in the cancer tissue due to difference in microvascular architecture. Emulsion has been prepared by manually mixing anticancer agent and Lipiodol. In novel method, detergent was added and SPG membrane, which has small uniform-sized multi pore inside, was used to prepare emulsion. Mono-dispersed w/o/w emulsion was obtained, which was verified by particle size measurement. Findings obtained in this experimental study will be fundamental to clinical application of the emulsion.

Free Research Field

放射線医学