Energy and ROS metabolism in radioresistant brain tumor stem cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06804
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Sun Lue 産業医科大学, 産業生態科学研究所, 訪問研究員 (40757704)
• Research Collaborator: YAMADA Shokei
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 脳腫瘍 / がん幹細胞 / 酸化ストレス / 解糖系 / ミトコンドリア呼吸 / 放射線抵抗性

Outline of Final Research Achievements

First of this study, we focus on Redox metabolism before and after irradiation in brain tumor stem-like cells (btSLCs). However we did not find noticeable difference between them. Next, we focus on energy metabolism in btSLCs. We found that btSLCs displayed lower oxidative phosphorylation activity and higher and lactate production than parental cells. Our findings also indicate that btSLCs metabolism plays an important role in maintaining radioresistance, and provide greater insight into the development of metabolic targeting radiotherapy to disrupt btSLCs.

Free Research Field

脳神経外科学