2016 Fiscal Year Final Research Report
Inhibitory effect of natural compounds with carboxylic group on active ghrelin production
| Project/Area Number |
15H06805
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 活性型グレリン / 抗肥満 / トリテルペン類 / カルボキシル基 / EGCG |
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| Outline of Final Research Achievements |
We screened for compounds with inhibitory effect on the production of active ghrelin, an appetite-stimulating peptide hormone. We found that triterpenes with carboxylic group, such as asiatic acid, oleanolic acid and glycyrrhetinic acid as well as epigallocatechin gallate (EGCG) suppressed active ghrelin production in the ghrelin-expressing cell line, AGS-GHRL8. Furthermore, oleanolic acid and EGCG decreased the plasma level of active ghrelin in mice. These triterpenes and EGCG are useful for the development of agents for prevention and treatment of obesity by suppressing active ghrelin production.
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| Free Research Field |
医療薬学
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