2016 Fiscal Year Final Research Report
Identification of new molecule for regulatory T cells in an anti-tumor immunity
| Project/Area Number |
15H06880
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University (2016)
National Cancer Center Japan (2015) |
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Principal Investigator |
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| Research Collaborator |
Nishikawa Hiroyoshi 名古屋大学, 大学院医学系研究科・分子細胞免疫学, 教授 (10444431)
Doi Toshihiko 国立がん研究センター先端医療開発センター免疫TR分野, 先端医療科長 (20522907)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 制御性T細胞 / Human immunology / 腫瘍浸潤リンパ球 |
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| Outline of Final Research Achievements |
A cancer immunotherapy using the immune systems attracts attention as a therapeutic method to novel cancer therapy. In this study, we analyzed immune responses of the stomach-cancer patient and was intended that we got knowledge to be connected for development of the new cancer immunotherapy.
After analyzing the immune cells in a blood or tumor tissue of the stomach cancer patients, there were more ratios of regulatory T cells which suppressed anti-tumor immune responses in the tumor tissues than blood, and they highly expressed cell surface molecules such as ICOS or CTLA-4. From these results, we suggested that expect an improvement effect of the anti-tumor immune responses by the removal of the regulatory T cells by ICOS and CTLA-4 marker.
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| Free Research Field |
腫瘍免疫
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