The involvement of leucine rich alpha-2 glycoprotein in the inflammasome of macrophage

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06918
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition
• Principal Investigator: Urushima Hayato 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 免疫シグナルプロジェクト, 協力研究員 (90755745)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 免疫学

Outline of Final Research Achievements

Leucine-rich α2-glycoprotein (LRG) has been identified as a disease activity marker of inflammatory diseases including inflammatory bowel disease (IBD). However, the roles of LRG in these diseases has not yet been clarified. We analyzed the function of LRG by using of DSS-induced colitis mice model of IBD. LRG deficiency led to decrease of infiltration of inflammatory cells such as neutrophil and macrophage. LRG upregulated the expression of endoglin which is an adhesion molecule via promotion of TGFβ-Smad1 pathway in vascular endothelium.
Taken together, our data suggest that LRG accelerates the traficking of leukocyte by upregulation of adhesion molecule in vascular endothelial cells, leading to progression of colonic inflammation.

Free Research Field

消化器内科学