神経回路の刺激と記録を同時に実行できる半導体オプトエレクトロニックデバイスの開発

2016 Fiscal Year Annual Research Report

• Project/Area Number: 15J02011
• Research Institution: Tohoku University
• Principal Investigator: 郭 媛元 東北大学, 医工学研究科, 特別研究員(DC2)
• Project Period (FY): 2015-04-24 – 2017-03-31
• Keywords: label-free detection / microscope / deep brain imading / multifunctional fiber

Outline of Annual Research Achievements

Current technologies for brain studies are electrophysiological recording and optical imaging, both of which retain unique yet complementary advantages, advancing our fundamental understanding of brain functions. However, electrophysiological recordings performed by microelectrode have low spatial resolution limited by the number and size of electrodes, while optical imaging relies on the bulky optics and fluorescent reporters of neuronal dynamics. Here a new class of implantable, biocompatible and label-free microscope device was introduced based on a field-effect sensor, i.e., the light-addressable potentiometric sensor (LAPS) with insulator-semiconductor structure, and flexible polymer fibers with electrodes and optical waveguide bundles, for deep brain imaging. The LAPS can convert the brain electric activities at the brain-insulator interface into carrier redistribution within the semiconductor via the field effect. Moreover, thanks to the photoelectronic effect of the semiconductor, localized surface potential change can be read out in the form of an ac photocurrent induced by a modulated light beam. In this way, image of brain activities can be performed by simultaneously mapping photocurrents at each measurement spot illuminated by light modulated at different frequencies. In this study, an implantable label-free microscope device based on field-effect sensor and multifunctional polymer fibers was developed. It has been demonstrated that this device can be implanted into the deep brain regions of mice and record low-frequency brain events with high fidelity.

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Massachusetts Institute of Technology/Virginia Tech(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Massachusetts Institute of Technology/Virginia Tech
• [Journal Article] One-step optogenetics with multifunctional flexible polymer fibers (2017)
  • Author(s): Seongjun Park, Yuanyuan Guo, Xiaoting Jia, Han Kyoung Choe, Benjamin Grena, Jeewoo Kang, Jiyeon Park, Chi Lu, Andres Canales, Ritchie Chen, Yeong Shin Yim, Gloria B Choi, Yoel Fink and Polina Anikeeva
  • Journal Title: Nature Neuroscience Volume: 20 Pages: 612 619
  • DOI: doi:10.1038/nn.4510
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Implantable polymer composite electrode with carbon nano fibers (CNF) aligned during thermal drawing as a reliable chronic neural interface (2017)
  • Author(s): Yuanyuan Guo
  • Organizer: 5th International Conference on Multifunctional, Hybrid and Nanomaterials
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2017-03-06 – 2017-03-10
  • Int'l Joint Research
• [Presentation] Novel flexible neural probes integrated with depth-dependent functionality for probing neural circuits at different brain regions with high precision (2016)
  • Author(s): Yuanyuan Guo
  • Organizer: Material Research Society Fall Meeting 2016
  • Place of Presentation: Boston, MA
  • Year and Date: 2016-11-27 – 2016-12-02
  • Int'l Joint Research