Study for regulatory mechanism of feeding-related phenomena by GLP-1

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00818
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Okayama University
• Principal Investigator: Kobashi Motoi 岡山大学, 医歯薬学総合研究科, 准教授 (80161967)
• Co-Investigator(Kenkyū-buntansha): 島谷 祐一 東京都市大学, 工学部, 准教授 (20154263) ; 美藤 純弘 岡山大学, 医歯薬学総合研究科, 助教 (20240872) ; 松尾 龍二 岡山大学, 医歯薬学総合研究科, 教授 (30157268) ; 藤田 雅子 岡山大学, 医歯薬学総合研究科, 助手 (40156881)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: GLP-1 / 嚥下 / 延髄 / 上喉頭神経 / ラット / 最後野 / 孤束核 / インクレチン

Outline of Final Research Achievements

The effects of glucagon like peptide-1 (GLP-1), which is appetite-reducing peptide, on reflex swallowing were examined using anaesthetized rats. GLP-1 suppressed reflex swallowing via the medial part of the NTS in the dorsal medulla. Orexin-A, which is appetite enhancing peptide, also suppressed reflex swallowing. The administration of orexin-A prior to the injection of GLP-1 attenuated the degree of suppression of the swallowing response induced by GLP-1-administration. Suppression of reflex swallowing by appetite-related peptides is thought to be helpful in keeping the ability of reflex swallowing constant in cooperation with the suppression ofappetite-enhancing peptides.

Free Research Field

口腔生理学　神経生理学