Elucidation of physiological function of colonic ALP and beta-glucosidase activities, and the effects of food factors on these enzymes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00836
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Fuji Women's University
• Principal Investigator: OKAZAKI Yukako 藤女子大学, 人間生活学部, 准教授 (80433415)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 大腸ALP活性 / ALP遺伝子 / 水溶性食物繊維 / 難消化性オリゴ糖 / 大腸内環境 / ラット

Outline of Final Research Achievements

This study demonstrated that consumption of fermentable non-digestible carbohydrates, including soluble dietary fiber and oligosaccharides, commonly elevated colonic ALP activity by up-regulation of the expression of IAP-I in rats fed a high-fat diet. On the other hand, β-glucosidase activity was not affected by the present dietary manipulation. Colon ALP correlated with colonic luminal variables such as mucins, cecal n-butyrate and fecal ratio of Bifidobacterium spp. that are associated with improvement of colonic environment. These results suggest that the elevating effects of fermentable non-digestible carbohydrates on colonic ALP might be important for protection of gut epithelial homeostasis.

Free Research Field

食物学，栄養学