2017 Fiscal Year Final Research Report
Relationship between low carbohydrate diet and impaired glucose tolerance frequently occurring in young Japanese women
| Project/Area Number |
15K00858
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 低糖質食 / インスリン初期分泌 / 耐糖能異常 |
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| Outline of Final Research Achievements |
In order to elucidate the cause of impaired glucose tolerance frequently occurred in young women, we examined whether insulin secretion ability is decreased by carbohydrate restriction.
Twenty-six healthy young women participated as subjects in a three-month open intervention trial taking 30% low-carbohydrate diet. We compared the results of 75 g OGTT before and after the intervention.
The insulin 30 minute value and the insulin inogenic index at 75 g OGTT decreased significantly. However, insulin sensitivity index was significantly increased and there was no significant difference in plasma glucose. As a result of examination using a generalized linear model, the factor affecting insulin secretion was only a decrease in carbohydrate intake. It was suggested that the low carbohydrate diet for 3 months reduced insulin secretion ability.
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| Free Research Field |
臨床栄養学
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